Description

Pyrimidine-2-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative of the pyrimidine heterocycle. This compound serves as a critical synthetic building block in advanced organic synthesis, enabling the introduction of the pyrimidine-2-sulfonyl moiety into target molecules. It is primarily utilized by pharmaceutical and agrochemical research & development teams for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key reagent for synthesizing sulfonamide-based drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and plant growth regulators with sulfonylurea-like activity.
• Material Science: Precursor for functional polymers and advanced organic materials requiring specific heterocyclic sulfonyl groups.
• Chemical Biology & Proteomics: Used in activity-based protein profiling (ABPP) and as a reactive handle for bioconjugation strategies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research laboratories for bespoke chemical synthesis projects.
• Academic Research: Employed in methodological development and heterocyclic chemistry studies within university and institutional labs.

Basic Information

Product Name	Pyrimidine-2-Sulfonyl Chloride
CAS No.	220548-03-8
Molecular Formula	C4H3ClN2O2S
Molecular Weight	178.60 g/mol
Synonyms	2-Pyrimidinesulfonyl chloride; Pyrimidine-2-sulfonyl chloride; 2-Chlorosulfonylpyrimidine; Pyrimidin-2-ylsulfonyl chloride; 2-Pyrimidinesulphonyl chloride; Pyrimidine-2-SO2Cl; 220548-03-8; Pyrimidine sulfonyl chloride
EINECS	Contact for details

Quality Control

Our Pyrimidine-2-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and NMR/IR for structural confirmation to ensure it meets the stringent requirements of research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.