Description

4-[4-(Trifluoromethyl)Pyridin-2-Yl]Morpholine is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of a pyridine-morpholine scaffold with a metabolically stable trifluoromethyl group, which is crucial for modulating the physicochemical and pharmacokinetic properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors, CNS-active compounds, and anti-infective agents.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized ligands in catalysis or for creating novel fluorinated polymers and liquid crystals.
• Chemical Biology Probe Development: Employed to synthesize tool compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring this specific fluorinated heterocycle.

Basic Information

Product Name	4-[4-(Trifluoromethyl)Pyridin-2-Yl]Morpholine
CAS No.	220459-55-2
Molecular Formula	C10H11F3N2O
Molecular Weight	232.20 g/mol
Synonyms	2-Morpholino-4-(trifluoromethyl)pyridine; 4-(4-Trifluoromethyl-2-pyridinyl)morpholine; 4-(4-Trifluoromethylpyridin-2-yl)morpholine; 4-(4-(Trifluoromethyl)pyridin-2-yl)morpholine; 4-(4-(Trifluoromethyl)-2-pyridinyl)morpholine; 4-(2-Pyridinyl)-4-(trifluoromethyl)morpholine (incorrect but common search variant); 220459-55-2
EINECS	Contact for details

Quality Control

Our 4-[4-(Trifluoromethyl)Pyridin-2-Yl]Morpholine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.