Description

2,4,6-Trifluorobenzenesulfonyl Chloride is a high-value fluorinated aromatic sulfonyl chloride building block. This compound is essential for introducing the highly reactive sulfonyl chloride group into target molecules, enabling the synthesis of sulfonamides and sulfonate esters. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients, where the trifluoromethyl and sulfonyl motifs are critical for modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of novel sulfonamide-based drug candidates, including protease inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and pesticides, where the fluorine atoms enhance lipophilicity and metabolic stability.
• Material Science: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and functional materials.
• Chemical Biology: Employed as a labeling or bioconjugation reagent for modifying proteins and other biomolecules.
• Organic Synthesis: A versatile reagent for constructing complex molecular architectures in academic and industrial research settings.

Basic Information

Product Name	2,4,6-Trifluorobenzenesulfonyl Chloride
CAS No.	220239-64-5
Molecular Formula	C6H2ClF3O2S
Molecular Weight	230.59 g/mol
Synonyms	2,4,6-Trifluorobenzene-1-sulfonyl chloride; 1,3,5-Trifluoro-2-sulfonylchloridobenzene; Benzenesulfonyl chloride, 2,4,6-trifluoro-; 2,4,6-Trifluorophenylsulfonyl chloride; 2,4,6-Trifluorobenzenesulphonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2,4,6-Trifluorobenzenesulfonyl Chloride is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.