Description

Talaporfin Sodium is a second-generation photosensitizer belonging to the chlorin class, developed for photodynamic therapy (PDT) and photodynamic diagnosis (PDD). Its primary value lies in its targeted activation by specific wavelengths of light, enabling precise therapeutic and diagnostic applications with reduced side effects. This compound is essential for pharmaceutical manufacturers and research institutions focused on developing advanced oncology treatments, particularly for cancers accessible to light, such as brain, lung, and esophageal tumors.

Application

• Photodynamic Therapy (PDT) for Oncology: As a key active pharmaceutical ingredient (API) in formulations targeting malignant tumors, including glioblastoma, non-small cell lung cancer, and early-stage esophageal cancer.
• Photodynamic Diagnosis (PDD): Used as a fluorescent imaging agent to visualize and demarcate tumor margins during surgical procedures, aiding in more complete resection.
• Pharmaceutical R&D: Serves as a critical reference standard and intermediate in the research and development of new photodynamic agents and combination therapies.
• Clinical Studies: Employed in investigational new drug (IND) applications and clinical trials for evaluating the safety and efficacy of novel PDT protocols.
• Bioconjugation Studies: Utilized in research to develop antibody-drug conjugates or nanoparticle-based delivery systems for targeted photodynamic therapy.

Basic Information

Product Name	Talaporfin Sodium
CAS No.	220201-34-3
Molecular Formula	C37H39N5Na4O9
Molecular Weight	797.70 g/mol
Synonyms	Talaporfin; LS 11; NPe6; Mono-L-aspartyl chlorin e6; MACE; Aspartyl Chlorin e6; Litx; Laserphyrin; Talaporfin sodium salt; Chlorin e6 monoaspartyl amide sodium salt
EINECS	Contact for details

Quality Control

Our Talaporfin Sodium is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing specifications such as HPLC purity, related substances, residual solvents, and heavy metals are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. Due to its hygroscopic nature, the container must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	Dark green to blackish green powder or solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 5.0 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.