Description

2'',4'',6''-Trifluoropropiophenone is a high-purity fluorinated aromatic ketone building block. This compound is valued for its trifluoromethyl-substituted aromatic ring, which imparts unique electronic and steric properties critical for advanced synthesis. It is primarily sought by R&D and production chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethyl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorine atoms contribute to efficacy and environmental persistence.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its fluorine content and aromatic structure.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, Friedel-Crafts acylations, and as a starting material for complex heterocyclic compounds in academic and industrial laboratories.
• Fluorine Chemistry Studies: An important compound for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in molecular design.

Basic Information

Product Name	2'',4'',6''-Trifluoropropiophenone
CAS No.	220141-69-5
Molecular Formula	C9H7F3O
Molecular Weight	188.15 g/mol
Synonyms	1-(2,4,6-Trifluorophenyl)propan-1-one; 2,4,6-Trifluoropropiophenone; 2',4',6'-Trifluoropropiophenone; Propiophenone, 2',4',6'-trifluoro-; α,α,α-Trifluoropropiophenone (ambiguous, verify structure); TFPP (abbreviation)
EINECS	Contact for details

Quality Control

Our 2'',4'',6''-Trifluoropropiophenone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory requirements for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.