Description

Ethyl 6-Fluoro-3,4-Dihydro-2H-1,4-Benzoxazine-2-Carboxylate is a high-purity fluorinated benzoxazine derivative, a key advanced pharmaceutical intermediate (API) and versatile building block in organic synthesis. Its value lies in its precise molecular architecture, which enables the efficient construction of complex molecules for drug discovery and development. This compound is essential for research chemists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate the 1,4-benzoxazine scaffold into new active compounds.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-infective drug research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, where the fluorinated benzoxazine core can enhance biological activity and environmental stability.
• Organic Synthesis Building Block: Serves as a versatile precursor for constructing complex heterocyclic compounds in medicinal and combinatorial chemistry.
• Research & Development: A valuable reagent for academic and industrial R&D labs focused on fluorinated heterocycles and structure-activity relationship (SAR) studies.
• Material Science Precursor: Potential use in the synthesis of specialty polymers and functional materials with unique optical or electronic properties.

Basic Information

Product Name	Ethyl 6-Fluoro-3,4-Dihydro-2H-1,4-Benzoxazine-2-Carboxylate
CAS No.	220120-59-2
Molecular Formula	C11H12FNO3
Molecular Weight	225.22 g/mol
Synonyms	Ethyl 6-Fluoro-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate; 2H-1,4-Benzoxazine-2-carboxylic acid, 6-fluoro-3,4-dihydro-, ethyl ester; 6-Fluoro-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid ethyl ester; Ethyl 6-fluoro-2H-1,4-benzoxazine-3(4H)-carboxylate; 220120-59-2; 6-Fluoro-1,4-benzoxazine-2-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 6-Fluoro-3,4-Dihydro-2H-1,4-Benzoxazine-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.