Description

1,2,3,4-Tetrahydro Staurosporine is a potent and selective derivative of the well-known kinase inhibitor staurosporine, with the CAS registry number 220038-19-7. This compound serves as a critical biochemical tool and a key intermediate in pharmaceutical research, particularly in the study of protein kinase signaling pathways. It is essential for researchers and developers in the life sciences, pharmaceutical, and biotechnology industries who require high-purity reference standards and building blocks for drug discovery.

Application

• Biochemical Research: Used as a potent and selective inhibitor in kinase assay development and signal transduction pathway studies.
• Pharmaceutical Intermediates: Serves as a key synthetic precursor in the development of novel therapeutic agents targeting specific kinases.
• Reference Standards: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Cell Biology Studies: Applied in vitro to investigate the role of specific kinases in cellular processes like proliferation, differentiation, and apoptosis.
• Drug Discovery Platforms: Integrated into high-throughput screening (HTS) assays to identify and characterize new drug candidates.
• Academic Research: Utilized in universities and research institutes for fundamental studies in medicinal chemistry and molecular pharmacology.

Basic Information

Product Name	1,2,3,4-Tetrahydro Staurosporine
CAS No.	220038-19-7
Molecular Formula	C28H28N4O3
Molecular Weight	468.55 g/mol
Synonyms	1,2,3,4-Tetrahydrostaurosporine; 1,2,3,4-Tetrahydro-staurosporine; 1,2,3,4-Tetrahydrostaurosporin; 4'-Demethylamino-4'-oxostaurosporine; K-252c; Antibiotic K-252c; 7-Oxo-7H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5-carboxylic acid, 6,7,12,13-tetrahydro-5-methyl-13-methylamino-, methyl ester; Staurosporine, 1,2,3,4-tetrahydro-
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydro Staurosporine is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The container should be kept in a dry, well-ventilated area and allowed to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.