Description

1,1',2,2',3,3',4,4'-Octahydro Staurosporine CAS NO 220038-18-6 is a chemically modified derivative of the potent, non-selective protein kinase inhibitor staurosporine. This hydrogenated analog is a critical research-grade biochemical used extensively in pharmacological and cell signaling studies. It is primarily utilized by pharmaceutical R&D laboratories and academic research institutions investigating kinase inhibition pathways, cancer biology, and neurodegenerative diseases.

Application

• Biochemical Research: A key tool for studying the mechanisms of protein kinase inhibition and intracellular signal transduction pathways.
• Oncology Research: Used in vitro and in vivo studies to investigate the effects of broad-spectrum kinase inhibition on tumor cell proliferation and apoptosis.
• Neuroscience Research: Applied in models studying the role of kinases in neuronal survival, synaptic plasticity, and neurodegenerative conditions.
• Pharmacology Profiling: Serves as a reference compound or lead structure in the screening and development of novel, more selective kinase inhibitor therapeutics.
• Cell Biology Studies: Utilized to modulate cellular processes such as differentiation, metabolism, and cell cycle progression in experimental settings.

Basic Information

Product Name	1,1',2,2',3,3',4,4'-Octahydro Staurosporine
CAS No.	220038-18-6
Molecular Formula	C28H30N4O3
Molecular Weight	470.56 g/mol
Synonyms	Octahydrostaurosporine; Dihydrostaurosporine (hydrogenated); Staurosporine, octahydro-; 7-Oxostaurosporine, octahydro-; Antibiotic AM-2282 derivative; K-252c derivative; Protein kinase C inhibitor (hydrogenated); (7S,8R,9R,13S,14S,16R)-13-(Dimethylamino)-16-methyl-7,8,9,11,12,13,14,15-octahydro-17H-4,7-methano-14,16-ethenocyclopenta[h][1,4,7,10]benzotetraoxacyclopentadecine-5,10,15(6H,16H)-trione
EINECS	Contact for details

Quality Control

Our high-purity biochemical is manufactured under controlled conditions to ensure batch-to-batch consistency for research applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each batch, documenting critical specifications. We adhere to stringent in-house quality standards suitable for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light. For long-term storage, consider storing desiccated under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.