Description

Ixabepilone is a semi-synthetic analog of the natural product epothilone B, functioning as a potent microtubule-stabilizing agent. This compound is of significant commercial and research interest due to its mechanism of action, which overcomes taxane resistance in certain cancer cell lines. It is primarily utilized by pharmaceutical R&D departments and manufacturers for the development and production of targeted oncology therapeutics. Ixabepilone CAS NO 219989-84-1 represents a critical intermediate and active pharmaceutical ingredient (API) in advanced cancer treatment research.

Application

• Pharmaceutical API Synthesis: Serves as the core active ingredient in the formulation of injectable oncology drugs.
• Cancer Research & Development: Used as a reference standard and investigational compound in preclinical and clinical studies targeting solid tumors, including breast cancer.
• Mechanistic Studies: Employed in biochemical research to study microtubule dynamics, stabilization, and mechanisms of drug resistance.
• Drug Discovery Programs: Acts as a lead compound or pharmacophore model for the design of next-generation antimitotic agents.
• Analytical Reference Standard: Utilized in quality control laboratories for HPLC, LC-MS, and NMR method development and validation.
• Combinatorial Therapy Development: Investigated in combination with other chemotherapeutic agents to enhance efficacy and overcome multidrug resistance.

Basic Information

Product Name	Ixabepilone
CAS No.	219989-84-1
Molecular Formula	C27H42N2O5S
Molecular Weight	506.70 g/mol
Synonyms	BMS-247550; Azaepothilone B; Ixempra (trade name); (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione; 16-Desmethyl-16-azaepothilone B
EINECS	Contact for details

Quality Control

Our Ixabepilone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (NMR, IR, MS), purity determination by HPLC, and control of specified impurities. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) detailing all test results against relevant specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); therefore, containers must be kept tightly sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.