Description

Pmx 53 CAS NO 219639-75-5 is a high-purity, synthetic peptide compound known for its potent and selective biological activity as a C5a receptor antagonist. This specificity makes it a critical research tool for investigating inflammatory pathways and immune system modulation. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for inflammatory and autoimmune diseases.

Application

• Pharmacological Research: A key reference standard and tool compound for studying the role of the complement C5a anaphylatoxin and its receptor (C5aR) in inflammatory processes.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and in vitro assays to identify and validate new anti-inflammatory drug candidates targeting the C5a/C5aR axis.
• Immunology Studies: Employed to dissect signaling pathways in immune cells (e.g., neutrophils, macrophages) to understand diseases like sepsis, rheumatoid arthritis, and ischemia-reperfusion injury.
• Biomarker Research: Serves as a precise inhibitor in experimental models to correlate C5a receptor activity with disease progression and potential diagnostic markers.
• Preclinical Model Validation: Used in animal models of inflammation to establish proof-of-concept for therapeutic strategies aimed at blocking C5a receptor signaling.

Basic Information

Product Name	Pmx 53
CAS No.	219639-75-5
Molecular Formula	C47H68N14O10S
Molecular Weight	997.2 g/mol
Synonyms	PMX-53; PMX53; AcF-[OPdChaWR]; C5a Receptor Antagonist, PMX-53; N-Acetyl-D-3-(2-naphthyl)alanyl-L-4-cyclohexylalanyl-L-α-aspartyl-L-α-(2,2-diphenylethyl)glycyl-L-tryptophyl-L-α-(3-methyl-2-butenyl)arginine; Cyclo(2-aminobutanoyl-O-2,6-dichlorobenzyl-L-tyrosyl-D-3-(2-naphthyl)alanyl-L-4-cyclohexylalanyl-L-α-aspartyl-L-α-(2,2-diphenylethyl)glycyl-L-tryptophyl-L-α-(3-methyl-2-butenyl)arginyl); H-AcF-[OPdChaWR]-OH
EINECS	Contact for details

Quality Control

Our Pmx 53 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, and is supplied with a detailed Certificate of Analysis (COA). We adhere to relevant standards for research-grade peptides to guarantee reliable and reproducible results for your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 97%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.