Description

Pmx-53| Acf-(Opdchawr) ,Acf-(Opdchawr) |Acf-(Op(D-Cha)Wr) is a synthetic peptide compound, specifically a potent and selective antagonist of the complement C5a receptor (C5aR/CD88). This compound is a critical research tool for studying inflammatory pathways and immune system modulation. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and immunological studies.

Application

• Pharmacological Research: As a reference standard and active agent in studies targeting the C5a receptor for anti-inflammatory drug discovery.
• Inflammation Models: Used in in vitro and in vivo models to inhibit C5a-mediated inflammatory responses, such as sepsis, arthritis, and ischemia-reperfusion injury.
• Immunology Studies: A key reagent for investigating the role of the complement system, anaphylatoxins, and neutrophil/monocyte chemotaxis.
• Biochemical Assay Development: Serves as a control compound in high-throughput screening (HTS) assays and receptor binding studies.
• Academic & Preclinical Development: Supports fundamental research and early-stage therapeutic development in autoimmune and inflammatory diseases.

Basic Information

Product Name	Pmx-53
CAS No.	219639-70-0
Molecular Formula	C44H62N12O9
Molecular Weight	902.04 g/mol
Synonyms	PMX-53; Ac-Phe-[Orn-Pro-D-cyclohexylalanine-Trp-Arg]; Cyclohexylalanine-Phe-Orn-Pro-D-Cha-Trp-Arg; C5a Receptor Antagonist PMX53; AcF-[OPdChaWR]; H-Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg]-OH; Complement C5a Antagonist; CD88 Antagonist
EINECS	Contact for details

Quality Control

Our Pmx-53 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, content, and chromatographic data are provided to ensure reproducibility and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Content)	≥ 98% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.