Description

Knk437 is a high-purity, small-molecule chemical compound with the CAS number 218924-25-5, widely recognized for its role as a potent and selective inhibitor of the BET bromodomain protein BRD4. This compound matters significantly in research and development for its ability to modulate epigenetic pathways, offering a powerful tool for investigating gene regulation and cellular processes. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, inflammation, and other disease areas where epigenetic dysregulation is a key target.

Application

• Epigenetics Research: A key tool for studying bromodomain and extra-terminal (BET) protein function and chromatin biology.
• Oncology Drug Discovery: Used in preclinical studies to evaluate the therapeutic potential of BRD4 inhibition in various cancer models.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening (HTS) campaigns.
• Inflammation and Immunology Studies: Investigated for its effects on inflammatory gene expression and immune cell function.
• Academic Research: Utilized in universities and research institutes for fundamental studies in transcriptional regulation.
• Chemical Probe Development: Acts as a starting point or comparator for the design of novel, more selective BET inhibitors.

Basic Information

Product Name	Knk437
CAS No.	218924-25-5
Molecular Formula	C₂₅H₂₀N₄O₃
Molecular Weight	424.45 g/mol
Synonyms	KNK 437; KNK-437; 2-[(4-Chlorophenyl)amino]-N-[[4-[(2-hydroxyethyl)amino]-6-methyl-2-pyrimidinyl]amino]carbonyl]benzamide; BRD4 Inhibitor KNK437; HSP Inhibitor KNK437; Benzamide, 2-[(4-chlorophenyl)amino]-N-[[4-[(2-hydroxyethyl)amino]-6-methyl-2-pyrimidinyl]amino]carbonyl]-; UNII-1B3P3VU5QJ
EINECS	Contact for details

Quality Control

Our Knk437 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and NMR/LC-MS for structural confirmation, to ensure compliance with high-grade research standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee reproducible and reliable performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or CoA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to maintain stability and purity. Avoid prolonged exposure to room temperature.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.