Description

Srpk Inhibitor CAS NO 218156-96-8 is a potent and selective small molecule inhibitor of serine/arginine-rich protein-specific kinases (SRPKs), key regulators of pre-mRNA splicing. This compound is a critical research tool for investigating the role of SRPKs in cellular processes and disease pathways, particularly in oncology and virology. It is essential for pharmaceutical R&D, academic research, and biotechnology applications focused on splicing regulation, cancer biology, and antiviral drug discovery.

Application

• Biomedical Research: Used as a selective chemical probe to study SRPK kinase function, signal transduction, and the regulation of alternative splicing in cell-based assays and in vitro studies.
• Oncology Research: Investigated for its potential to inhibit tumor growth and angiogenesis by modulating VEGF splicing, making it relevant for cancer biology and preclinical therapeutic development.
• Virology Studies: Applied in research to understand viral replication mechanisms, as SRPKs can be involved in the life cycle of certain viruses, aiding in the identification of novel antiviral targets.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening (HTS) and structure-activity relationship (SAR) studies for developing novel kinase inhibitors.
• Biochemical Assays: Employed in enzymatic assays to determine IC50 values, kinase selectivity profiles, and for validating other SRPK inhibitors.

Basic Information

Product Name	Srpk Inhibitor CAS NO 218156-96-8
CAS No.	218156-96-8
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	SRPIN340; N-(2-(1H-Indol-3-yl)ethyl)-4-(5-methyl-1H-pyrazol-3-ylamino)quinoline-3-carboxamide; SRPK Inhibitor; Serine-Arginine Protein Kinase Inhibitor; SRPK1/2 Inhibitor; 3-Quinolinecarboxamide, N-[2-(1H-indol-3-yl)ethyl]-4-[(5-methyl-1H-pyrazol-3-yl)amino]-; CAS 218156-96-8
EINECS	Contact for details

Quality Control

Our Srpk Inhibitor is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We adhere to relevant industry standards for research chemicals, and custom purity grades or analytical services are available upon request to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.