Description

Carvedilol n-β-D-Glucuronide is a key glucuronide metabolite of the widely used β-blocker carvedilol. This compound is of significant importance in pharmaceutical research and development, particularly for metabolism and pharmacokinetic studies. It serves as a critical reference standard for analytical laboratories in the pharmaceutical and biotechnology sectors, enabling accurate quantification and characterization of carvedilol's metabolic pathways.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the calibration of analytical instruments and validation of bioanalytical methods.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for studying the Phase II conjugation metabolism, bioavailability, and clearance mechanisms of carvedilol.
• Bioanalytical Assay Development: Used in the development and validation of high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS/MS) assays for biological matrices.
• Toxicology and Safety Assessment: Employed in metabolite identification and safety studies to understand the pharmacological and toxicological profile of carvedilol metabolites.
• Quality Control in Manufacturing: Acts as a benchmark for ensuring the purity and consistency of carvedilol-based drug products and related substances.
• Academic and Clinical Research: Supports fundamental research into cardiovascular drug metabolism and personalized medicine approaches.

Basic Information

Product Name	Carvedilol n-β-D-Glucuronide
CAS No.	216973-69-2
Molecular Formula	C30H40N2O10
Molecular Weight	588.65 g/mol
Synonyms	Carvedilol Glucuronide; Carvedilol N-Glucuronide; 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol β-D-Glucopyranosiduronic Acid; (2S,3S,4S,5R,6S)-6-[1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propan-2-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic Acid; Carvedilol β-D-Glucuronide; Carvedilol N-β-Glucuronide
EINECS	Contact for details

Quality Control

Our Carvedilol n-β-D-Glucuronide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for use as a reference standard. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines for reference materials to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.