Description

2-Methoxy-4-Methylbenzenesulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a key sulfonylation reagent, enabling the introduction of the sulfonyl functional group to create complex molecules with tailored properties. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for synthesizing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and pesticides where the sulfonyl moiety is integral to biological activity.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the development of specialty polymers, such as sulfonated polymers for ion-exchange membranes.
• Dye and Pigment Manufacturing: Employed in the synthesis of sulfonated dyes and colorants to enhance solubility and fiber affinity.
• Chemical Research & Development: A valuable reagent for method development, library synthesis, and exploring new chemical entities in academic and industrial R&D labs.
• Ligand and Catalyst Preparation: Used to functionalize ligands and create novel organocatalysts or metal-organic frameworks (MOFs).

Basic Information

Product Name	2-Methoxy-4-Methylbenzenesulfonyl Chloride
CAS No.	216394-11-5
Molecular Formula	C8H9ClO3S
Molecular Weight	220.67 g/mol
Synonyms	4-Methyl-2-methoxybenzenesulfonyl chloride; 2-Methoxy-4-methylbenzene-1-sulfonyl chloride; 4-Methyl-2-methoxy-1-benzenesulfonyl chloride; 2-Methoxy-p-toluenesulfonyl chloride; p-Tolyl 2-methoxy sulfonyl chloride; (2-Methoxy-4-methylphenyl)sulfonyl chloride; 1-(Chlorosulfonyl)-2-methoxy-4-methylbenzene; 4-Methyl-2-methoxybenzenesulfonylchloride
EINECS	Contact for details

Quality Control

Our production of 2-Methoxy-4-Methylbenzenesulfonyl Chloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure consistency and reliability. We provide detailed Certificates of Analysis (COA) with each shipment, documenting key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the rigorous demands of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.