Description

Su5402 is a potent and selective small molecule inhibitor of Fibroblast Growth Factor Receptor (FGFR) tyrosine kinase activity. This compound is a critical research tool for investigating cellular signaling pathways, angiogenesis, and tumorigenesis in preclinical studies. It is primarily utilized by researchers and scientists in the pharmaceutical, biotechnology, and academic sectors for drug discovery and molecular biology applications.

Application

• Biochemical Research: Used as a selective inhibitor to study FGFR1, FGFR2, and FGFR3 signaling pathways in cell-based assays.
• Cancer Research: Investigated for its anti-angiogenic and anti-proliferative effects in various tumor models, including breast cancer and glioblastoma.
• Drug Discovery: Serves as a reference compound and a starting point for the development of novel tyrosine kinase inhibitor therapeutics.
• Stem Cell & Developmental Biology: Applied in studies to understand the role of FGF signaling in embryonic development, differentiation, and tissue regeneration.
• Signal Transduction Studies: A key reagent for dissecting the downstream effects of FGFR activation, including MAPK/ERK and PI3K/AKT pathways.

Basic Information

Product Name	Su5402
CAS No.	215543-92-3
Molecular Formula	C₁₆H₁₀FN₃O₃
Molecular Weight	311.27 g/mol
Synonyms	SU 5402; SU-5402; 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone; 2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid; FGFR Inhibitor SU5402; Fibroblast Growth Factor Receptor Inhibitor SU5402; VEGFR2 Inhibitor SU5402
EINECS	Contact for details

Quality Control

Our Su5402 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to meet our stringent specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container should be kept in a dry environment and allowed to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.