Description

(R)-Butaprost, Free Acid is a high-purity, enantiomerically pure prostaglandin analog. This compound is a critical chiral intermediate and reference standard for advanced pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the life sciences sector for developing novel therapeutics, particularly in the fields of ophthalmology and pulmonary medicine.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of prostaglandin-based active pharmaceutical ingredients (APIs).
• Reference Standard: Used in analytical method development, validation, and quality control for drug substance and product testing.
• Ophthalmic Research: Investigated for the development of new treatments for glaucoma and ocular hypertension.
• Pulmonary Research: Studied for potential applications in modulating bronchial and vascular smooth muscle activity.
• Biochemical Research: Employed as a selective ligand to study prostaglandin receptor (EP2) signaling pathways and functions.
• Process Chemistry: Serves as a critical starting material or intermediate in asymmetric synthesis and process scale-up.

Basic Information

Product Name	(R)-Butaprost, Free Acid
CAS No.	215168-33-5
Molecular Formula	C₂₃H₃₈O₅
Molecular Weight	394.55 g/mol
Synonyms	(R)-Butaprost; (R)-TR-4979; (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-4-(3-methoxyphenoxy)-1-buten-1-yl]cyclopentyl]-5-Heptenoic Acid; (R)-enantiomer of Butaprost; Prostaglandin E2 (PGE2) receptor (EP2) agonist (R-form); TR-4979 (R-enantiomer); Butaprost Free Acid (R)
EINECS	Contact for details

Quality Control

Our (R)-Butaprost, Free Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. For long-term storage, desiccate to protect against moisture. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.