Description

8-iso-15(R)-Prostaglandin F2Alpha is a specific stereoisomer of an isoprostane, a class of prostaglandin-like compounds formed in vivo from the free radical-catalyzed peroxidation of arachidonic acid. This compound is of significant value as a high-purity reference standard and research biochemical for investigating oxidative stress, lipid peroxidation, and related biological pathways. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and diagnostic kit manufacturers focused on cardiovascular, neurological, and inflammatory disease models.

Application

• Biomedical Research Standard: Used as an analytical reference standard in LC-MS/MS and ELISA methods for the precise quantification of isoprostanes in biological samples (e.g., plasma, urine, tissue).
• Oxidative Stress Studies: A critical tool for studying the mechanisms and biomarkers of oxidative damage in models of aging, neurodegenerative diseases (e.g., Alzheimer's, Parkinson's), and atherosclerosis.
• Pharmacology & Drug Discovery: Employed in screening assays to evaluate the efficacy of novel antioxidant or anti-inflammatory compounds designed to modulate isoprostane pathways.
• Clinical Diagnostics Development: Serves as a key calibrant and quality control material in the development and validation of commercial diagnostic tests for oxidative stress status.
• Nutritional & Metabolic Research: Used to assess the impact of diets, supplements, and lifestyle interventions on lipid peroxidation and redox balance.
• Toxicology Assessments: Applied in studies evaluating the oxidative damage potential of environmental toxins, pharmaceuticals, or industrial chemicals.

Basic Information

Product Name	8-iso-15(R)-Prostaglandin F2Alpha
CAS No.	214748-65-9
Molecular Formula	C₂₀H₃₄O₅
Molecular Weight	354.48 g/mol
Synonyms	8-iso-15(R)-PGF2α; 15(R)-8-iso-Prostaglandin F2α; 8-iso-15-epi-Prostaglandin F2α; (5Z)-7-{(1R,2R,3R,5S)-5-[(1E,3S)-3-Hydroxy-1-octen-1-yl]-2-[(1R)-1-hydroxypropyl]-3-hydroxycyclopentyl}-5-heptenoic Acid; 8-iso-PGF2α III; iPF2α-III; 15(R)-8-iso-PGF2α
EINECS	Contact for details

Quality Control

Our 8-iso-15(R)-Prostaglandin F2Alpha is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, critical for research and diagnostic applications. Each lot undergoes comprehensive analytical characterization using HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with GMP/GLP guidelines for research materials.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area designated for laboratory chemicals.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.