Description

4-(2-Carboxyethenyl)Phenyl β-D-Glucopyranosiduronic Acid is a high-purity biochemical reference standard and synthetic intermediate of significant importance in pharmaceutical research and development. This compound is valued for its role as a key metabolite or precursor in the study of drug metabolism and pharmacokinetics (DMPK). It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in analytical method development, impurity profiling, and advanced organic synthesis.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of drug metabolites in bioanalytical studies.
• Drug Metabolism & Pharmacokinetics (DMPK): Serves as a critical metabolite standard for in vitro and in vivo studies to understand drug clearance pathways.
• Impurity Synthesis and Characterization: Employed as a starting material or intermediate for synthesizing specified impurities and degradation products to support regulatory filings.
• Analytical Method Development: Acts as a benchmark compound for developing and validating HPLC, LC-MS, and other chromatographic methods in quality control labs.
• Bioconjugation Research: Utilized in the development of targeted drug delivery systems and antibody-drug conjugates (ADCs) due to its reactive carboxylic acid and glucuronide moieties.
• Enzymatic Substrate: Potential substrate for studies involving β-glucuronidase enzymes and related biochemical pathways.

Basic Information

Product Name	4-(2-Carboxyethenyl)Phenyl β-D-Glucopyranosiduronic Acid
CAS No.	214689-30-2
Molecular Formula	C15H16O9
Molecular Weight	340.28 g/mol
Synonyms	4-Vinylbenzoic Acid β-D-Glucuronide; (E)-4-(2-Carboxyvinyl)phenyl β-D-Glucopyranosiduronic Acid; p-Carboxycinnamyl Alcohol Glucuronide; trans-4-Carboxystyryl β-D-Glucuronide; 4-(Carboxyethenyl)phenyl Glucuronide; Glucuronic Acid, 4-(2-Carboxyethenyl)phenyl β-D-Glucopyranosiduronic Acid Ester; 214689-30-2; 4-Carboxyvinylphenyl β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our 4-(2-Carboxyethenyl)Phenyl β-D-Glucopyranosiduronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the stringent requirements for research and reference standards. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. Due to its hygroscopic nature, the container should be kept in a desiccated environment. Handle the material under an inert atmosphere if prolonged exposure is anticipated during weighing.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.