Description

Kotalanol is a potent, naturally derived α-glucosidase inhibitor originally isolated from the medicinal plant *Salacia reticulata*. It serves as a critical reference standard and pharmacological tool for diabetes research, drug discovery, and enzyme mechanism studies due to its high selectivity and nanomolar-level inhibitory activity. Researchers and pharmaceutical developers rely on Kotalanol CAS NO 214491-07-3 for assay development, structural-activity relationship (SAR) analysis, and preclinical validation of anti-hyperglycemic agents.

Application

• Primary reference standard for HPLC and LC-MS quantification in pharmacokinetic and metabolic stability studies
• Key biochemical probe for in vitro and cell-based α-glucosidase inhibition assays
• Lead compound in structure-guided design of next-generation anti-diabetic therapeutics
• Critical control material for analytical method validation in regulatory submissions (FDA, EMA, PMDA)
• Component in high-fidelity enzyme kinetics kits for academic and industrial enzymology labs
• Stability-indicating impurity reference for Salacia-derived nutraceutical formulations

Basic Information

Product Name	Kotalanol
CAS No.	214491-07-3
Molecular Formula	C30H48O10
Molecular Weight	568.70 g/mol
Synonyms	Kotalanol; (3β,4α,5β,6α)-3-[(2S,3R,4S,5S,6R)-2-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-4,5,6-trihydroxy-1-methyl-2-oxabicyclo[2.2.2]octan-7-one; Salacinol analog; Kotalanol A; 214491-07-3; NSC 755323; UNII-7X9Q8Z8J1F
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for identity (IR, HPLC retention time, and mass spectrometry), purity (≥98.5% by HPLC), and absence of specified impurities (heavy metals, residual solvents, microbial contamination). Testing adheres to ICH Q2(R2) guidelines and supports GMP-compliant R&D environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (nitrogen or argon) to prevent oxidation and degradation. Keep desiccated; avoid exposure to ambient humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	m/z 569.3 [M+H]+ (ESI+)
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Single impurity ≤0.5%; Total impurities ≤1.5%
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Heavy Metals	≤10 ppm
Water Content (KF)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.