Description

o-Desmethyl Galantamine is a key pharmaceutical intermediate and metabolite of the acetylcholinesterase inhibitor galantamine. This compound is of significant interest in the research and development of treatments for neurodegenerative disorders, particularly Alzheimer's disease. It is primarily utilized by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in advanced drug synthesis and metabolic studies.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of galantamine hydrobromide and related active pharmaceutical ingredients (APIs).
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to understand the pharmacokinetics and metabolism of galantamine.
• Neurological Research: Serves as a tool compound in preclinical research for investigating cholinergic pathways and cognitive function.
• Process Development: Employed in the optimization and scaling of synthetic routes for galantamine-based therapeutics.
• Quality Control: Acts as a high-purity reference material for impurity profiling and assay validation of galantamine drug substances and products.

Basic Information

Product Name	o-Desmethyl Galantamine
CAS No.	213983-94-9
Molecular Formula	C16H21NO3
Molecular Weight	275.35 g/mol
Synonyms	N-Desmethylgalantamine; O-Desmethyl Galantamine; Galantamine Impurity C; Galantamine Metabolite; 4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol; (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol
EINECS	Contact for details

Quality Control

Our o-Desmethyl Galantamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.