Description

Nfκb Inhibitor CAS NO 213546-53-3 is a potent and selective small molecule inhibitor of the nuclear factor kappa B (NF-κB) signaling pathway, a critical regulator of immune and inflammatory responses. This compound is essential for researchers and developers in life sciences seeking to modulate cellular processes linked to inflammation, immunity, and cell survival. It is primarily utilized in pharmaceutical R&D, academic research, and biotechnology for investigating disease mechanisms and developing novel therapeutic agents.

Application

• Biomedical Research: A key tool for studying the NF-κB pathway's role in inflammation, apoptosis, and cellular stress responses in vitro and in vivo.
• Drug Discovery & Development: Used as a reference standard or lead compound in screening assays and preclinical studies for anti-inflammatory, anti-cancer, and immunomodulatory drugs.
• Cell Signaling Studies: Employed to dissect complex signal transduction networks and validate targets downstream of cytokine receptors, Toll-like receptors (TLRs), and other NF-κB activators.
• Inflammation Models: Applied in experimental models to inhibit NF-κB activation and assess therapeutic potential in conditions like rheumatoid arthritis, inflammatory bowel disease, and sepsis.
• Oncology Research: Investigated for its ability to sensitize cancer cells to chemotherapy or radiation by blocking NF-κB-mediated survival signals.
• Academic & Institutional Labs: Serves as a critical reagent for graduate and postdoctoral research projects focused on molecular biology and pharmacology.

Basic Information

Product Name	Nfκb Inhibitor CAS NO 213546-53-3
CAS No.	213546-53-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	NF-κB Inhibitor; NFκB Signaling Inhibitor; BAY 11-7082; (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile; BAY 11-7085; BAY11-7082; BAY 117082; NF-κB Activation Inhibitor
EINECS	Contact for details

Quality Control

Our Nfκb Inhibitor is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation and purity assessment via advanced chromatographic methods. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥95%
Water Content	Contact for details
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.