Description

Purvalanol A CAS NO 212844-53-6 is a potent and highly selective purine-based inhibitor of cyclin-dependent kinases (CDKs), specifically targeting CDK2 and CDK1. This compound is a critical research tool for studying cell cycle regulation, apoptosis, and signal transduction pathways in various biological systems. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology research and drug discovery.

Application

• Biochemical Research: A key reagent for investigating the mechanisms of cell cycle progression and the role of specific CDKs in cellular proliferation.
• Oncology & Cancer Research: Used in in vitro and cell-based assays to study tumor growth inhibition and to validate CDK targets for potential therapeutic development.
• Signal Transduction Studies: Employed to dissect kinase-dependent signaling cascades and their impact on cellular fate decisions.
• Drug Discovery & Development: Serves as a pharmacological tool and a reference standard in high-throughput screening campaigns and lead optimization for CDK inhibitor programs.
• Academic Research: Widely used in university laboratories for fundamental studies in molecular biology, biochemistry, and pharmacology.

Basic Information

Product Name	Purvalanol A
CAS No.	212844-53-6
Molecular Formula	C₁₉H₁₉N₅O₂
Molecular Weight	349.39 g/mol
Synonyms	Purvalanol A; 2-(1R)-1-(6-Amino-9H-purin-9-yl)ethyl-5-hydroxy-4-(1-methylethyl)-2,5-dihydro-1H-pyrrole-1,3(2H)-dione; NG 95; NG-95; CDK Inhibitor Purvalanol A; (R)-(-)-Purvalanol A; (R)-Purvalanol A
EINECS	Contact for details

Quality Control

Our Purvalanol A is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR/LC-MS for structural confirmation, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.