Description

9-Oxo-11Alpha,16R-Dihydroxy-17-Cyclobutyl-5Z,13E-Dien-1-Oic Acid CAS NO 212310-16-2 is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is of significant value in the synthesis of novel prostaglandin analogs and other bioactive molecules, where precise structural control is paramount for efficacy and safety. It is primarily required by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in the fields of ophthalmology, cardiovascular medicine, and inflammation.

Application

• Key Intermediate for Prostaglandin Analog Synthesis: Serves as a critical building block in the multi-step synthesis of potent prostaglandin receptor agonists.
• Pharmaceutical R&D: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and the creation of new chemical entities (NCEs).
• Ophthalmic Drug Development: A precursor in the research and production of potential drugs for treating glaucoma and ocular hypertension.
• Cardiovascular Research: Employed in the investigation of compounds that may regulate blood pressure and vascular tone.
• Anti-inflammatory Agent Synthesis: Utilized as a starting material for developing novel non-steroidal anti-inflammatory drugs (NSAIDs) with improved profiles.
• Process Chemistry & Scale-up: Supports route scouting, optimization, and cGMP manufacturing for clinical trial material and commercial API production.

Basic Information

Product Name	9-Oxo-11Alpha,16R-Dihydroxy-17-Cyclobutyl-5Z,13E-Dien-1-Oic Acid
CAS No.	212310-16-2
Molecular Formula	C21H30O5
Molecular Weight	362.46 g/mol
Synonyms	11α,16R-Dihydroxy-9-oxo-17-cyclobutylprosta-5Z,13E-dien-1-oic Acid; 17-Cyclobutyl Prostaglandin Intermediate; Travoprost Intermediate; 9-Keto Prostaglandin Analog; 212310-16-2; AGN 192024 Intermediate; AL-6221 Intermediate; Prostaglandin F2α Cyclobutyl Analogue
EINECS	Contact for details

Quality Control

Our 9-Oxo-11Alpha,16R-Dihydroxy-17-Cyclobutyl-5Z,13E-Dien-1-Oic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and comprehensive identification and impurity profiling. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the stringent requirements of pharmaceutical development and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.