Description

D-[3-13C]Ribose is a stable isotope-labeled analog of the essential pentose sugar, D-ribose, specifically enriched with carbon-13 at the 3-position. This precise labeling makes it an indispensable tool for advanced metabolic research and nuclear magnetic resonance (NMR) spectroscopy studies. It is primarily used by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require high-purity, isotopically defined compounds for tracing biochemical pathways and developing analytical standards.

Application

• Metabolic Flux Analysis (MFA): Used as a 13C-labeled tracer to map and quantify intracellular metabolic pathways in microbial, plant, and mammalian systems.
• NMR Spectroscopy: Serves as a critical standard and substrate for structural elucidation and dynamic studies of nucleic acids, glycans, and other ribose-containing biomolecules.
• Pharmaceutical Research: Employed in the development and testing of nucleoside-based drugs (e.g., antivirals, anticancer agents) to study drug metabolism and mechanism of action.
• Biochemical Assay Development: Acts as a calibrated internal standard in mass spectrometry (MS) and LC-MS/MS methods for accurate quantification of ribose and its derivatives.
• Isotope-Labeled Precursor Synthesis: A key starting material for the synthesis of more complex 13C-labeled nucleotides, coenzymes (e.g., ATP, NADH), and RNA oligomers.

Basic Information

Product Name	D-[3-13C]Ribose
CAS No.	211947-12-5
Molecular Formula	C413CH10O5
Molecular Weight	151.12 g/mol (for 13C1 labeled form)
Synonyms	D-Ribose-3-13C; (3R,4S,5R)-5-(Hydroxymethyl)oxolane-2,3,4-triol-3-13C; 3-13C-D-Ribose; Ribose (D-), 3-13C-labeled; D-(-)-Ribose-3-13C; 13C1-Ribose; Isotopically labeled D-ribose
EINECS	Contact for details

Quality Control

Every batch of D-[3-13C]Ribose is produced and analyzed under strict quality management protocols to ensure exceptional isotopic and chemical purity, critical for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic enrichment (atom % 13C), chemical purity, and specific analytical data (NMR, HPLC, MS) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99% at C-3 position
Specific Optical Rotation	-20.0° to -23.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.