Description

Jak3 Inhibitor CAS NO 211555-04-3 is a potent and selective small molecule inhibitor of Janus kinase 3 (JAK3), a key enzyme in cytokine signaling pathways. This compound is a critical research tool for investigating the role of JAK3 in immune cell function and for the preclinical development of novel immunomodulatory and anti-inflammatory therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on autoimmune diseases, organ transplant rejection, and hematological cancers.

Application

• Biomedical Research: Used as a selective pharmacological tool to study JAK-STAT signaling pathways in cellular and animal models of disease.
• Drug Discovery & Development: Serves as a reference compound or lead molecule in high-throughput screening and structure-activity relationship (SAR) studies for new JAK3 inhibitors.
• Immunology Studies: Applied to investigate T-cell and NK-cell activation, proliferation, and function, providing insights into autoimmune disorders like rheumatoid arthritis and psoriasis.
• Oncology Research: Explored in preclinical models for hematologic malignancies where JAK3 signaling is implicated, such as certain leukemias and lymphomas.
• Transplant Research: Studied for its potential to modulate immune responses and prevent graft-versus-host disease (GvHD) and organ transplant rejection.

Basic Information

Product Name	Jak3 Inhibitor CAS NO 211555-04-3
CAS No.	211555-04-3
Molecular Formula	C₂₂H₂₁N₅O₂
Molecular Weight	387.44 g/mol
Synonyms	WHI-P154; 4-(3'-Hydroxyanilino)-6,7-dimethoxyquinazoline; 6,7-Dimethoxy-4-(3-hydroxyphenylamino)quinazoline; JANEX-1; JAK3 Inhibitor VI; Tyrphostin AG 490; NSC 693036; 4-[(3-Hydroxyphenyl)amino]-6,7-dimethoxyquinazoline
EINECS	Contact for details

Quality Control

Our Jak3 Inhibitor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	Off-white to yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.