Description

8-Iso Prostaglandin A1 is a specialized isoprostane analog of prostaglandin A1, a member of the cyclopentenone prostaglandin family. This compound is valued in research for its role as a biomarker of oxidative stress and for studying the biological effects of reactive electrophilic species. It serves as a critical reference standard and biochemical tool for scientists in pharmaceutical R&D, clinical diagnostics, and academic research focused on inflammation, lipid peroxidation, and cellular signaling pathways.

Application

• Biomarker Research: Used as a precise analytical standard for the quantification of isoprostanes, key indicators of oxidative stress in biological systems.
• Pharmaceutical Development: Serves as a reference compound in the discovery and validation of drugs targeting oxidative stress-related diseases, such as cardiovascular disorders and neurodegenerative conditions.
• Clinical Studies: Employed in method development and validation for mass spectrometry (LC-MS/MS) assays to measure oxidative damage in patient samples.
• Biochemical Research: Utilized to investigate the biological activity and signaling mechanisms of cyclopentenone prostaglandins and their analogs in cell culture models.
• Reference Material: Provides a high-purity standard for quality control in the production of diagnostic kits and research reagents.

Basic Information

Product Name	8-Iso Prostaglandin A1
CAS No.	211186-29-7
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.47 g/mol
Synonyms	8-iso-PGA1; 8-iso-Prostaglandin A1; 15-Deoxy-δ¹²,¹⁴-PGJ₂ isomer; (5Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoic Acid; 8-epi-PGA1; IsoPGA1
EINECS	Contact for details

Quality Control

Our 8-Iso Prostaglandin A1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.