Description

Methyl 6-Fluoro-5-Methylpyridine-3-Carboxylate is a high-purity fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for its unique reactivity and structural features.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized heterocyclic compounds for advanced materials, such as organic semiconductors.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated pyridine motifs.
• Academic and R&D Laboratories: Used in medicinal chemistry and process chemistry research for method development and exploratory synthesis.

Basic Information

Product Name	Methyl 6-Fluoro-5-Methylpyridine-3-Carboxylate
CAS No.	211122-38-2
Molecular Formula	C8H8FNO2
Molecular Weight	169.15 g/mol
Synonyms	6-Fluoro-5-methylnicotinic acid methyl ester; Methyl 6-fluoro-5-methylnicotinate; 3-Pyridinecarboxylic acid, 6-fluoro-5-methyl-, methyl ester; 6-Fluoro-5-methyl-pyridine-3-carboxylic acid methyl ester; 211122-38-2; Methyl 5-methyl-6-fluoronicotinate
EINECS	Contact for details

Quality Control

Our production of Methyl 6-Fluoro-5-Methylpyridine-3-Carboxylate adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization and impurity profiling. Certificates of Analysis (COA) detailing purity, identity, and all relevant specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.