Description

17-Trans Prostaglandin E3 is a specialized bioactive lipid mediator and a stereoisomer of the naturally occurring Prostaglandin E3 (PGE3). This compound is of significant interest for advanced biochemical and pharmacological research due to its distinct biological activity profile compared to its cis-isomer. It serves as a critical reference standard and synthetic intermediate for researchers and developers in the pharmaceutical and life sciences sectors, particularly those investigating inflammation, immune modulation, and metabolic pathways.

Application

• Pharmaceutical Research & Development: As a high-purity reference standard for analytical method development, validation, and quality control of related drug substances.
• Biochemical Studies: Used in in vitro and in vivo research to study the structure-activity relationships (SAR) of prostaglandin analogs and their effects on specific receptors (e.g., EP receptors).
• Metabolic Pathway Analysis: A key tool for investigating the role of specialized pro-resolving mediators (SPMs) and eicosanoid signaling in inflammation resolution and metabolic disorders.
• Synthetic Intermediate: Employed in the custom synthesis of novel prostaglandin derivatives and analogs for therapeutic discovery programs.
• Academic Research: Essential for universities and research institutes conducting fundamental studies in lipidomics, cell biology, and molecular pharmacology.

Basic Information

Product Name	17-Trans Prostaglandin E3
CAS No.	210979-33-2
Molecular Formula	C20H32O5
Molecular Weight	352.47 g/mol
Synonyms	(5Z,11α,13E,15S,17E)-11,15-Dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid; 17-trans-PGE3; (17E)-PGE3; 17-trans-Prostaglandin E3; PGE3 (17-trans-isomer); 9-Oxo-11α,15S-dihydroxy-(5Z,13E,17E)-prostatrienoic acid
EINECS	Contact for details

Quality Control

Our 17-Trans Prostaglandin E3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the rigorous demands of pharmaceutical R&D and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area designated for research chemicals.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.