Description

1-(6-Chloro-5-(Trifluoromethyl)Pyridin-2-Yl)Piperazine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a distinct trifluoromethylpyridine core. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, especially in the areas of central nervous system (CNS) and anti-infective drugs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting neurological and psychiatric disorders.
• Agrochemical Research: Used in the development of new generation pesticides and herbicides, leveraging the biological activity of the trifluoromethylpyridine moiety.
• Chemical Biology & Proteomics: Serves as a versatile scaffold or linker in the design of chemical probes for target identification and validation studies.
• Material Science: Potential precursor for specialty polymers and advanced organic electronic materials due to its aromatic and heterocyclic structure.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the life sciences industry.

Basic Information

Product Name	1-(6-Chloro-5-(Trifluoromethyl)Pyridin-2-Yl)Piperazine Hydrochloride
CAS No.	210821-63-9
Molecular Formula	C10H10ClF3N3·HCl
Molecular Weight	302.57 g/mol (Free base: 265.66 g/mol)
Synonyms	1-[6-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazine hydrochloride; 2-(Piperazin-1-yl)-6-chloro-5-(trifluoromethyl)pyridine hydrochloride; 6-Chloro-5-(trifluoromethyl)-2-(1-piperazinyl)pyridine hydrochloride; 1-(6-Chloro-5-trifluoromethyl-pyridin-2-yl)-piperazine HCl; 210821-63-9; 1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine HCl salt
EINECS	Contact for details

Quality Control

Our production of 1-(6-Chloro-5-(Trifluoromethyl)Pyridin-2-Yl)Piperazine Hydrochloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with customer specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.