Description

1-(Trifluoroacetyl)Indoline-5-Sulfonyl Chloride is a high-value, reactive sulfonyl chloride derivative used as a key synthetic intermediate in advanced organic chemistry. Its core value lies in enabling the efficient introduction of the indoline-5-sulfonyl moiety, a crucial step in constructing complex molecules with targeted biological activity. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactive sulfonyl chloride group.
• Chemical Biology Probes: Serves as a precursor for synthesizing activity-based probes (ABPs) or affinity labels to study protein function and interactions.
• Material Science: Can be utilized in the synthesis of specialized polymers or functional materials that incorporate sulfonamide linkages.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	1-(Trifluoroacetyl)Indoline-5-Sulfonyl Chloride
CAS No.	210691-38-6
Molecular Formula	C11H7ClF3NO3S
Molecular Weight	325.69 g/mol
Synonyms	1-(Trifluoroacetyl)-2,3-dihydro-1H-indole-5-sulfonyl chloride; 5-(Chlorosulfonyl)-1-(trifluoroacetyl)indoline; 1H-Indole-5-sulfonyl chloride, 2,3-dihydro-1-(trifluoroacetyl)-; Indoline-5-sulfonyl chloride, 1-(trifluoroacetyl)-; 1-(Trifluoroacetyl)indoline-5-sulfonyl chloride; 210691-38-6; 5-Sulfonylchloride-1-(trifluoroacetyl)indoline
EINECS	Contact for details

Quality Control

Our 1-(Trifluoroacetyl)Indoline-5-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), identity (IR, NMR), and impurity profiles. Our quality management system is designed to meet the rigorous standards expected by the pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.