Description

3,5-Difluorobenzenesulfonyl Chloride is a high-purity, reactive organosulfur intermediate essential for advanced chemical synthesis. Its core value lies in its dual functionality, serving as a versatile sulfonylation and coupling reagent to introduce the 3,5-difluorophenylsulfonyl moiety into target molecules. This compound is critically needed by R&D and production chemists in the pharmaceutical and agrochemical industries for constructing complex active ingredients, particularly in the development of new drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs), including kinase inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the production of modern herbicides, fungicides, and insecticides that require the difluorophenylsulfonyl group for enhanced activity and selectivity.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced functional materials.
• Chemical Research: A valuable reagent in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis during drug discovery.
• Dye and Pigment Manufacturing: Intermediate in the synthesis of specialized dyes and pigments where fluorine substitution alters lightfastness and color properties.

Basic Information

Product Name	3,5-Difluorobenzenesulfonyl Chloride
CAS No.	210532-25-5
Molecular Formula	C6H3ClF2O2S
Molecular Weight	212.60 g/mol
Synonyms	3,5-Difluorobenzene-1-sulfonyl chloride; Benzenesulfonyl chloride, 3,5-difluoro-; 3,5-Difluorophenylsulfonyl chloride; 3,5-DFBS-Cl; 3,5-Difluorobenzenesulphonyl chloride
EINECS	Contact for details

Quality Control

Our 3,5-Difluorobenzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.