Description

A-Methyl-D,L-Tryptophan-1-14C Methyl Ester is a carbon-14 labeled derivative of tryptophan, a critical amino acid. This radiolabeled compound is essential for advanced metabolic and pharmacokinetic studies, providing researchers with a precise tracer to track biochemical pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs (Contract Research Organizations) engaged in drug discovery and development.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of novel pharmaceutical compounds.
• Biochemical Pathway Analysis: Enables the detailed tracing of tryptophan and its derivative pathways in biological systems.
• Proteomics and Biomarker Research: Serves as a tool in mass spectrometry-based studies for protein labeling and quantification.
• Preclinical Research: Critical for in vitro and in vivo studies to understand the mechanism of action and safety profile of drug candidates.
• Isotope Dilution Mass Spectrometry (IDMS): Acts as an internal standard for the highly accurate quantification of analytes in complex matrices.

Basic Information

Product Name	A-Methyl-D,L-Tryptophan-1-14C Methyl Ester
CAS No.	210357-35-0
Molecular Formula	C13H1614CN2O2
Molecular Weight	~246.73 g/mol (for 12C form)
Synonyms	1-14C-α-Methyl-DL-Tryptophan Methyl Ester; Methyl 2-Amino-3-(1H-indol-3-yl)-2-methylpropanoate-1-14C; DL-α-Methyltryptophan-1-14C Methyl Ester; AMT-1-14C Methyl Ester; (RS)-2-Amino-3-(1H-indol-3-yl)-2-methylpropanoic Acid Methyl Ester-1-14C; Carbon-14 Labeled α-Methyltryptophan Methyl Ester; Tryptophan Derivative-1-14C
EINECS	Contact for details

Quality Control

Every batch of A-Methyl-D,L-Tryptophan-1-14C Methyl Ester is manufactured and analyzed under strict quality control protocols to ensure the highest standards of radiochemical purity and chemical identity. Our quality system emphasizes traceability and reproducibility for research integrity. A comprehensive Certificate of Analysis (COA) detailing specific activity, purity by HPLC, radiochemical purity, and analytical chromatograms is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is sensitive to moisture and should be handled under inert conditions where specified. For long-term storage of solutions, consult the specific handling guidelines provided in the technical data sheet.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (RAD-HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (if supplied as solution)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.