Description

Z-Lehd-Fmk is a potent and selective caspase inhibitor, widely recognized in biochemical and pharmaceutical research. This compound is crucial for studying apoptotic pathways and developing therapeutic interventions for diseases involving dysregulated cell death. It is an essential tool for researchers and developers in the fields of pharmacology, oncology, and neurobiology.

Application

• Biochemical Research: A key reagent for investigating the mechanisms of apoptosis and caspase enzyme activity.
• Pharmaceutical Development: Used as a reference standard and lead compound in the discovery of novel anti-apoptotic drugs.
• Oncology Studies: Employed to understand tumor cell resistance and to screen for potential chemotherapeutic agents.
• Neurodegenerative Disease Research: Applied in models of diseases like Alzheimer's and Parkinson's to study neuronal cell death.
• Inflammatory Pathway Analysis: Utilized to dissect the role of caspases in inflammation and immune responses.
• Cell Culture & Assay Development: Serves as a critical control in high-throughput screening assays and cell-based experiments.

Basic Information

Product Name	Z-Lehd-Fmk
CAS No.	210345-04-3
Molecular Formula	C24H31FN4O7
Molecular Weight	506.53 g/mol
Synonyms	Z-LEHD-FMK; Z-Leu-Glu(OMe)-His-Asp(OMe)-FMK; Caspase-9 Inhibitor II; (Benzyloxycarbonyl)-Leu-Glu(OMe)-His-Asp(OMe)-fluoromethyl ketone; Z-LEHD-FMK Caspase Inhibitor; Ac-LEHD-CHO; LEHD-FMK; Caspase 9 Inhibitor
EINECS	Contact for details

Quality Control

Our Z-Lehd-Fmk is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to verify identity and potency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.