Description

Caspase-1 Inhibitor Tfa Salt CAS NO 210345-00-9 is a potent and selective small molecule inhibitor of the caspase-1 enzyme, a key mediator of the inflammatory response. This compound is essential for researchers and developers investigating pyroptosis and the role of interleukin-1β (IL-1β) in inflammatory and autoimmune diseases. It is primarily utilized in pharmaceutical R&D, academic research, and the development of novel therapeutics targeting conditions like sepsis, gout, and neurodegenerative disorders.

Application

• Biochemical Research: A critical tool for studying the mechanisms of inflammasome activation, pyroptosis, and IL-1β processing in cellular models.
• Drug Discovery & Development: Used as a reference standard and lead compound in the screening and development of novel anti-inflammatory therapeutics.
• Inflammatory Disease Modeling: Employed in in vitro and in vivo studies to validate caspase-1 as a therapeutic target for conditions such as rheumatoid arthritis, multiple sclerosis, and type 2 diabetes.
• Academic & Pharmaceutical R&D: Serves as a key reagent in high-throughput screening (HTS) assays and target validation studies within research laboratories.
• Cell Biology Studies: Used to inhibit caspase-1 activity to elucidate its specific role in cellular pathways separate from other caspases.

Basic Information

Product Name	Caspase-1 Inhibitor Tfa Salt
CAS No.	210345-00-9
Molecular Formula	C17H13F3N4O5S
Molecular Weight	442.37 g/mol
Synonyms	Ac-Tyr-Val-Ala-Asp-2,6-dimethylbenzoyloxymethylketone Trifluoroacetate Salt; Ac-YVAD-CMK Tfa Salt; Caspase-1 Inhibitor II, Ac-YVAD-CMK; Acetyl-Tyr-Val-Ala-Asp-chloromethylketone TFA; Interleukin-1β Converting Enzyme (ICE) Inhibitor; Z-YVAD-FMK (related analog); VX-765 (Belnacasan) precursor compound
EINECS	Contact for details

Quality Control

Our Caspase-1 Inhibitor Tfa Salt is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.