Description

Caspase-8 Inhibitor Ii CAS NO 210344-98-2 is a potent and selective cell-permeable peptide inhibitor of caspase-8, a key initiator caspase in the extrinsic apoptosis pathway. This compound is essential for researchers investigating programmed cell death, cellular signaling, and inflammation in various disease models. It is primarily used by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, immunology, and neurodegenerative disease research.

Application

• Apoptosis Research: A critical tool for specifically inhibiting caspase-8 activity to study the extrinsic apoptosis pathway in cell culture models.
• Drug Discovery Screening: Used in high-throughput assays to identify and validate novel therapeutic compounds targeting caspase-8 related pathways.
• Disease Mechanism Studies: Enables investigation into the role of caspase-8 in cancer, autoimmune disorders, and inflammatory conditions.
• Biochemical Assay Development: Serves as a reference standard and positive control in enzymatic activity assays for caspase-8.
• Signal Transduction Analysis: Helps delineate crosstalk between apoptosis, necroptosis, and other cell death mechanisms.
• Academic & Institutional Research: Fundamental reagent for basic science research in molecular biology and cell death laboratories.

Basic Information

Product Name	Caspase-8 Inhibitor Ii
CAS No.	210344-98-2
Molecular Formula	C24H34N4O5S
Molecular Weight	490.62 g/mol
Synonyms	Z-IETD-FMK; Benzyloxycarbonyl-Ile-Glu-Thr-Asp-fluoromethyl ketone; Caspase-8 Inhibitor Z-IETD-FMK; Z-Ile-Glu-Thr-Asp-FMK; IETD-FMK; Caspase 8 Inhibitor II; (2S)-5-[[(2S)-1-[[(2S)-4-[[(2S)-1-[[(2S)-1-[[benzyloxy]carbonyl]-2-methylbutyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-fluoro-4-methyl-1-oxopentan-2-yl] carbamate
EINECS	Contact for details

Quality Control

Our Caspase-8 Inhibitor Ii is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and functional activity assays to confirm inhibitory potency. Certificates of Analysis (COA) detailing purity, assay results, and storage recommendations are provided with every shipment to support your research compliance and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption. The product is stable under these conditions for at least two years from the date of receipt.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Biological Activity (IC50)	≤ 50 nM (Caspase-8)
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.