Description

Z-Devd-Fmk is a potent and selective caspase-3 inhibitor, widely recognized in biochemical and pharmaceutical research. This compound is essential for studying apoptotic pathways and developing therapeutic interventions for diseases involving dysregulated cell death. It is a critical tool for researchers and developers in the fields of pharmacology, oncology, and neuroscience, where precise modulation of caspase activity is required.

Application

• Apoptosis Research: Used as a key biochemical tool to selectively inhibit caspase-3 activity in cell-based and in vitro studies of programmed cell death.
• Drug Discovery & Development: Serves as a reference compound and pharmacophore model for designing novel therapeutics targeting caspase-mediated diseases.
• Neuroscientific Studies: Applied in research models of neurodegenerative conditions (e.g., Alzheimer's, Parkinson's, stroke) to investigate the role of caspase-3 in neuronal apoptosis.
• Oncology Research: Utilized to probe the mechanisms of cancer cell survival and resistance, and to evaluate potential chemosensitizing agents.
• Inflammatory Disease Models: Employed in studies of autoimmune and inflammatory disorders where caspase-3 activation contributes to pathology.
• Biochemical Assay Development: Acts as a control inhibitor in high-throughput screening (HTS) assays and enzymatic activity tests.

Basic Information

Product Name	Z-Devd-Fmk
CAS No.	210344-95-9
Molecular Formula	C24H32FN3O7
Molecular Weight	493.53 g/mol
Synonyms	Z-DEVD-FMK; Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK; Caspase-3 Inhibitor II; Z-DEVD-Fluoromethyl Ketone; (Benzyloxycarbonyl)-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone; Ac-DEVD-CHO (related aldehyde); DEVD-FMK; Caspase 3/7 Inhibitor
EINECS	Contact for details

Quality Control

Our Z-Devd-Fmk is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation by NMR and Mass Spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and stability data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.