Description

Z-Vdvad-Fmk CAS NO 210344-96-2 is a potent and selective fluoromethyl ketone-based caspase inhibitor, widely recognized as a key biochemical tool in apoptosis research. This compound is essential for studying programmed cell death pathways and validating drug targets in various disease models. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for high-throughput screening and mechanistic studies.

Application

• Apoptosis Research: Used as a specific inhibitor to study caspase-3 and related caspase activities in cellular death pathways.
• Drug Discovery & Validation: Serves as a critical reference compound and positive control in high-throughput screening assays for novel therapeutic agents.
• Biochemical Assay Development: Employed in the development and optimization of in vitro enzymatic assays to measure caspase inhibition.
• Neurodegenerative Disease Models: Applied in research models for diseases like Alzheimer's and Parkinson's to investigate the role of apoptosis.
• Oncology Research: Utilized to probe resistance mechanisms and sensitize cancer cell lines to chemotherapeutic agents.
• Academic & Institutional Research: A fundamental reagent for basic research in cell biology and signal transduction laboratories worldwide.

Basic Information

Product Name	Z-Vdvad-Fmk
CAS No.	210344-96-2
Molecular Formula	C27H38FN3O8
Molecular Weight	551.61 g/mol
Synonyms	Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK; Z-VDVAD-FMK; Caspase-2 Inhibitor I; (Benzyloxycarbonyl)-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethyl ketone; Z-VD(OCH3)VAD(OCH3)-FMK; Ac-DEVD-CHO analog; Caspase Inhibitor, Fluoromethyl Ketone Type; Benzyloxycarbonyl-Val-Asp-Val-Ala-Asp-fluoromethylketone
EINECS	Contact for details

Quality Control

Every batch of Z-Vdvad-Fmk is manufactured under strict quality protocols and undergoes comprehensive analytical testing to ensure identity, purity, and biological activity. We provide full traceability and Certificates of Analysis (COA) with each shipment, detailing results from HPLC, NMR, and MS. Our quality system is designed to meet the stringent requirements of research and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Biological Activity (IC50)	≤ 50 nM (Caspase-2)
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.