Description

2-Amino-3,4,8-Trimethyl-3H-Imidazo[4,5-F]Quinoxaline-2-14C is a carbon-14 labeled derivative of a heterocyclic aromatic amine, a critical tool for advanced research and development. This isotopically labeled compound is essential for conducting precise metabolic, pharmacokinetic, and environmental fate studies where tracking the molecule is required. It is primarily utilized by pharmaceutical researchers, toxicologists, and analytical chemists working in drug discovery, safety assessment, and mechanistic biochemistry.

Application

• Tracer Studies in Metabolism and Pharmacokinetics (PK/PD): Used as a radiolabeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) of heterocyclic amine compounds in biological systems.
• Drug Discovery and Development: Facilitates the quantitative analysis of drug candidates and their metabolites during preclinical and clinical research phases.
• Toxicological and Carcinogenicity Research: Enables detailed investigation into the bioactivation, DNA adduct formation, and metabolic pathways of potentially mutagenic compounds.
• Environmental Fate and Food Safety Studies: Applied in research to track the transformation and persistence of similar amine structures in environmental or food matrices.
• Analytical Method Development: Serves as an internal standard or reference material in the development and validation of sensitive analytical methods like LC-MS/MS.
• Biochemical Pathway Elucidation: Aids in mapping specific enzymatic pathways and reaction mechanisms involving complex heterocyclic amines.

Basic Information

Product Name	2-Amino-3,4,8-Trimethyl-3H-Imidazo[4,5-F]Quinoxaline-2-14C
CAS No.	210100-52-0
Molecular Formula	C₁₁H₁₁N₅ (with 14C label at the 2-position)
Molecular Weight	~213.24 g/mol (exact mass depends on 14C enrichment)
Synonyms	2-Amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline-2-14C; 2-Amino-3,4,8-trimethyl-3H-imidazo[4,5-f]quinoxaline (14C-labeled); 14C-MeIQx; [2-14C]-2-Amino-3,4,8-trimethyl-3H-imidazo[4,5-f]quinoxaline; Radiolabeled MeIQx; Carbon-14 Labeled Heterocyclic Aromatic Amine; 2-14C-ATMIQ
EINECS	Contact for details

Quality Control

Every batch of our carbon-14 labeled compounds is produced and analyzed under stringent conditions to ensure radiochemical purity, chemical purity, and specific activity meet the exacting requirements of research applications. Quality is verified via advanced analytical techniques including HPLC with radiometric detection and MS. A comprehensive Certificate of Analysis (COA) detailing purity, specific activity (mCi/mmol or GBq/mmol), solvent composition, and analytical chromatograms is provided with each shipment to ensure full traceability and compliance with laboratory standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at or below -20°C. The product is light-sensitive (store away from light). Solutions should be prepared in appropriate solvents and used promptly to minimize decomposition. Always adhere to local regulations for the safe handling and disposal of radioactive materials.

Specification

Item	Specification
Appearance	Solid (Color to be specified on COA)
Identification (HPLC)	Conforms to reference standard
Chemical Purity (HPLC)	≥ 95%
Radiochemical Purity	≥ 97%
Specific Activity	50-60 mCi/mmol (1.85-2.22 GBq/mmol) [Customizable]
Solvent (if supplied as solution)	Specified on COA (e.g., Ethanol, Toluene)
Concentration	Specified on COA (e.g., 1.0 mCi/mL, 0.1 mg/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.