Description

Ly411575 is a potent and selective small molecule inhibitor of the γ-secretase enzyme complex. This compound is a critical research tool for investigating the Notch signaling pathway, which plays a fundamental role in cell differentiation, proliferation, and apoptosis. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurology, and developmental biology studies.

Application

• Notch Signaling Pathway Research: A key reagent for studying the role of γ-secretase and Notch in cellular communication and disease mechanisms.
• Oncology Research: Used in preclinical studies to investigate the inhibition of Notch signaling as a potential therapeutic strategy for various cancers, including T-cell acute lymphoblastic leukemia (T-ALL) and solid tumors.
• Neurological Disease Models: Employed in research models for Alzheimer's disease and other neurological conditions where γ-secretase activity and amyloid precursor protein (APP) processing are of interest.
• Stem Cell & Developmental Biology: Facilitates studies on cell fate determination, differentiation, and tissue development by modulating Notch pathway activity.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in assay development and screening campaigns targeting γ-secretase.
• Biochemical & Cellular Assays: Used to validate assay systems and study enzyme kinetics and inhibition profiles in vitro and in cell-based models.

Basic Information

Item	Details
Product Name	Ly411575
CAS No.	209984-57-6
Molecular Formula	C₂₃H₂₂F₂N₂O₄
Molecular Weight	428.43 g/mol
Synonyms	N-[2,3-Difluoro-6-(2-hydroxyethoxy)phenyl]-4-methoxy-3-(3-pyridinyl)benzenesulfonamide; (S)-N2-(2,3-Difluoro-6-(2-hydroxyethoxy)benzyl)-N1-((S)-1-(4-fluorophenyl)ethyl)-2-methylpropane-1,2-diamine; γ-secretase inhibitor LY411575; LY-411575; LY 411575; Merck 411575; Notch inhibitor LY411575
EINECS	Contact for details

Quality Control

Our Ly411575 is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.