Description

Vx-745 CAS NO 209410-46-8 is a potent and selective small molecule inhibitor of p38α mitogen-activated protein (MAP) kinase, a key enzyme involved in the regulation of inflammatory cytokine production. This compound is of significant value for pharmaceutical research and development, particularly in the investigation of novel anti-inflammatory and autoimmune disease therapeutics. It is primarily needed by research institutions, pharmaceutical companies, and biotechnology firms engaged in drug discovery programs targeting conditions such as rheumatoid arthritis, Crohn's disease, and other cytokine-mediated disorders.

Application

• Pharmaceutical Research & Development: As a critical biochemical tool for studying the p38 MAPK signaling pathway and its role in inflammation and cellular stress responses.
• Drug Discovery Programs: Serving as a reference compound or lead molecule in the development of new anti-inflammatory and immunomodulatory agents.
• Preclinical Studies: Used in in vitro and in vivo models to validate p38α as a therapeutic target and to assess the efficacy of novel inhibitors.
• Biochemical Assay Development: Employed as a standard in high-throughput screening (HTS) and kinase selectivity profiling assays.
• Academic Research: Utilized in university and institutional labs for fundamental research into signal transduction mechanisms and disease pathology.

Basic Information

Product Name	Vx-745
CAS No.	209410-46-8
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	VX-745; 5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one; BIRB 796 analogue; p38α MAP kinase inhibitor VX-745; 1,6-Pyrimidopyridazinone, 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-; Vertex 745
EINECS	Contact for details

Quality Control

Our Vx-745 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results. We adhere to high standards suitable for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.