Description

Pyridine, 2-Fluoro-5-[[(2R)-1-Methyl-2-Azetidinyl]Methoxy]- (9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its specific chiral azetidine and fluoropyridine structure. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), enabling the development of targeted therapeutics with enhanced efficacy. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, particularly for projects involving nicotinic acetylcholine receptor (nAChR) modulators and central nervous system (CNS) agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies for designing nAChR-targeting compounds.
• Preclinical Development: Serves as a critical raw material for producing batches of novel APIs for toxicology and early-phase studies.
• Chemical Synthesis: Employed in complex organic synthesis requiring a fluorinated, methoxy-substituted pyridine moiety with a chiral azetidine side chain.

Basic Information

Product Name	Pyridine, 2-Fluoro-5-[[(2R)-1-Methyl-2-Azetidinyl]Methoxy]- (9Ci)
CAS No.	209327-74-2
Molecular Formula	C10H13FN2O
Molecular Weight	196.22 g/mol
Synonyms	2-Fluoro-5-[[(2R)-1-methyl-2-azetidinyl]methoxy]pyridine; (R)-2-Fluoro-5-((1-methylazetidin-2-yl)methoxy)pyridine; 2-Fluoro-5-(((2R)-1-methylazetidin-2-yl)methoxy)pyridine; 209327-74-2; UNII-9F8T7J4F3I; 9F8T7J4F3I; AZD-0328 Intermediate; AZD0328 Related Compound
EINECS	Contact for details

Quality Control

Our Pyridine, 2-Fluoro-5-[[(2R)-1-Methyl-2-Azetidinyl]Methoxy]- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.