Description

Epothilone F is a potent, naturally occurring microtubule-stabilizing agent belonging to the epothilone class of macrolides. This compound is of significant interest in advanced pharmaceutical research due to its mechanism of action, which is analogous to paclitaxel but with potential advantages in overcoming certain forms of drug resistance. It serves as a critical intermediate and reference standard for researchers in oncology and medicinal chemistry, particularly those developing next-generation chemotherapeutic agents. The global availability of high-purity Epothilone F CAS NO 208518-52-9 supports innovation in drug discovery and preclinical development pipelines.

Application

• Pharmaceutical Research & Development: As a key reference standard and biochemical tool for studying microtubule dynamics and cell cycle inhibition.
• Oncology Drug Discovery: Serves as a lead compound or intermediate for the synthesis of novel anti-cancer agents and analogs.
• Mechanistic Studies: Used in vitro and in vivo to investigate mechanisms of action, drug resistance, and combination therapies.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) assays to identify and validate new therapeutic targets.
• Academic Research: Utilized in university and institutional labs for fundamental research in cell biology and chemical biology.
• GMP Intermediate: Potential use as a starting material or intermediate in the controlled synthesis of active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.

Basic Information

Product Name	Epothilone F
CAS No.	208518-52-9
Molecular Formula	C26H39NO6S
Molecular Weight	493.66 g/mol
Synonyms	Epothilone F; 4,8-Dimethyl-12-(2-methyl-4-thiazolyl)-10-oxa-2-azabicyclo[12.3.1]octadeca-1(18),14,16-triene-5,9,13,17-tetrone; (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione; 16-Desmethyl-16-hydroxyepothilone B; 26-Hydroxyepothilone B
EINECS	Contact for details

Quality Control

Our Epothilone F is produced and handled under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters. We support compliance with global regulatory frameworks, and custom purity grades or specific impurity profiles can be discussed to meet your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers should be allowed to equilibrate to room temperature before opening to minimize condensation, and handling should be performed under controlled conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.