Description

2-(Trifluoromethyl)-3-Pyridinecarboxylic Acid Ethyl Ester is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the trifluoromethyl group and the ester functionality, enabling precise molecular modifications. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers and liquid crystals.
• Chemical Research: A versatile reagent in academic and industrial laboratories for methodology development and exploring new fluorination chemistry.
• Ligand and Catalyst Development: Employed in the synthesis of complex ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2-(Trifluoromethyl)-3-Pyridinecarboxylic Acid Ethyl Ester
CAS No.	208517-35-5
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	Ethyl 2-(Trifluoromethyl)nicotinate; Ethyl 2-(Trifluoromethyl)-3-pyridinecarboxylate; 3-Pyridinecarboxylic acid, 2-(trifluoromethyl)-, ethyl ester; 2-Trifluoromethyl-nicotinic acid ethyl ester; 2-(Trifluoromethyl)pyridine-3-carboxylic acid ethyl ester; Nicotinic acid, 2-(trifluoromethyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)-3-Pyridinecarboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, organic solvents, fluorides, and strong alkalis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.