Description

5-Chloro-2,3-Dibromo-1-Fluorobenzene is a highly functionalized halogenated benzene derivative, serving as a critical multi-purpose building block in advanced organic synthesis. Its unique combination of chlorine, bromine, and fluorine substituents on a single aromatic ring makes it an exceptionally versatile intermediate for introducing specific halogen functionalities into target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex active ingredients, as well as in materials science for creating specialized polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly where specific halogen atoms are required for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its halogen pattern for targeted pesticidal activity.
• Material Science Building Block: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its ability to modify electronic properties and intermolecular interactions.
• Cross-Coupling Reactions: Serves as a substrate in various palladium-catalyzed reactions (e.g., Suzuki, Stille, Negishi) where the bromine atoms act as excellent leaving groups.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine substitution adjacent to other halogens on aromatic ring reactivity and physical properties.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D.

Basic Information

Product Name	5-Chloro-2,3-Dibromo-1-Fluorobenzene
CAS No.	208186-78-1
Molecular Formula	C6H2Br2ClF
Molecular Weight	288.34 g/mol
Synonyms	1-Fluoro-5-chloro-2,3-dibromobenzene; 2,3-Dibromo-5-chloro-1-fluorobenzene; 5-Chloro-2,3-dibromofluorobenzene; Benzene, 5-chloro-2,3-dibromo-1-fluoro-; 5-Chloro-2,3-dibromo-1-fluorobenzene; 1-Fluoro-2,3-dibromo-5-chlorobenzene
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,3-Dibromo-1-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality supports applications in GMP and ISO-compliant environments, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.