Description

9Alpha,15R-Dihydroxy-11Beta-Fluoro-15-(2,3-Dihydro-1H-Inden-2-Yl)-16,17,18, 19,20-Pentanor-Prosta-5Z,13E-Dien-1-Oic Acid, Isopropyl Ester is a high-purity synthetic prostaglandin analog, a key advanced intermediate in pharmaceutical research and development. Its complex, modified structure is engineered to provide targeted biological activity, making it a critical building block for novel therapeutic agents. This compound is essential for R&D teams and manufacturers in the pharmaceutical and biotechnology sectors focused on developing new ophthalmic, cardiovascular, and anti-inflammatory treatments.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel prostaglandin-based active pharmaceutical ingredients (APIs).
• Ophthalmic Drug Development: Used in research for next-generation glaucoma and ocular hypertension treatments, such as prostaglandin analogs like latanoprost and travoprost derivatives.
• Cardiovascular Research: Investigated for its potential effects on vasodilation and platelet aggregation in preclinical studies.
• Anti-inflammatory Agent Synthesis: Serves as a core structure for developing new compounds targeting inflammatory pathways.
• Biochemical Research: Utilized as a high-purity standard and probe in pharmacological studies to understand prostaglandin receptor interactions.
• Process Chemistry & Scale-up: Employed in optimizing synthetic routes for the commercial manufacturing of prostaglandin drugs.

Basic Information

Item	Details
Product Name	9Alpha,15R-Dihydroxy-11Beta-Fluoro-15-(2,3-Dihydro-1H-Inden-2-Yl)-16,17,18, 19,20-Pentanor-Prosta-5Z,13E-Dien-1-Oic Acid, Isopropyl Ester
CAS No.	208114-93-6
Molecular Formula	C29H39FO5
Molecular Weight	486.62 g/mol
Synonyms	Isopropyl 9α,15R-dihydroxy-11β-fluoro-15-(2,3-dihydro-1H-inden-2-yl)-16,17,18,19,20-pentanor-5Z,13E-prostadienoate; 11β-Fluoro-15R-hydroxy-15-(2,3-dihydro-1H-inden-2-yl)-16,17,18,19,20-pentanor-PGF2α isopropyl ester; Travoprost Related Compound C; Prostaglandin F2α Fluoroindenyl Analogue, Isopropyl Ester; AL-5848 (Isopropyl Ester); 15R-Fluprostenol Isopropyl Ester (structural analog); 9,11β,15-Trihydroxy-15-(2,3-dihydro-1H-inden-2-yl)prosta-5,13-dien-1-oic acid, 11β-fluoro-, isopropyl ester
EINECS	Contact for details

Quality Control

Our 9Alpha,15R-Dihydroxy-11Beta-Fluoro-15-(2,3-Dihydro-1H-Inden-2-Yl)-16,17,18, 19,20-Pentanor-Prosta-5Z,13E-Dien-1-Oic Acid, Isopropyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, keep the primary container sealed within a secondary, light-proof container. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.