Description

Tariquidar is a potent and selective third-generation P-glycoprotein (P-gp) inhibitor, a key compound in pharmaceutical research and development. Its primary value lies in its ability to modulate multidrug resistance (MDR) by blocking the efflux pump activity of P-gp, thereby potentially enhancing the bioavailability and efficacy of co-administered chemotherapeutic agents. This makes it an essential research tool for scientists in oncology, pharmacology, and drug delivery, focusing on overcoming treatment resistance in cancer and improving central nervous system drug penetration. Tariquidar CAS NO 206873-63-4 is supplied as a high-purity reference standard and active pharmaceutical ingredient (API) intermediate for preclinical and clinical studies.

Application

• Oncology Research: Used as a pharmacological tool to study and overcome P-glycoprotein-mediated multidrug resistance in various cancer cell lines and animal models.
• Drug Delivery Enhancement: Investigated in combination therapies to improve the intracellular concentration and efficacy of chemotherapeutic drugs like paclitaxel, doxorubicin, and vinblastine.
• Blood-Brain Barrier (BBB) Studies: Applied in neuroscience research to inhibit P-gp at the BBB, facilitating the study of central nervous system drug penetration for conditions like epilepsy and brain tumors.
• Pharmacokinetic & Pharmacodynamic (PK/PD) Modeling: Serves as a critical agent in studies assessing the absorption, distribution, and interaction profiles of co-administered drugs.
• API Intermediate: Employed as a high-purity building block in the synthesis and development of novel therapeutic formulations and clinical trial materials.
• Biochemical Assay Development: Utilized as a standard or inhibitor in vitro assays designed to screen for P-gp activity and new modulator compounds.

Basic Information

Product Name	Tariquidar
CAS No.	206873-63-4
Molecular Formula	C₃₄H₃₃N₃O₆
Molecular Weight	571.65 g/mol
Synonyms	XR9576; N-(2-((4-(2-(3,4-Dimethoxyphenyl)ethyl)phenyl)amino)-2-oxoethyl)-N,4,5-trimethyl-3-((2-methylquinolin-4-yl)methoxy)benzamide; Tariquidar dimethanesulfonate salt (common salt form); P-Glycoprotein Inhibitor III; Anthranilic acid derivative P-gp inhibitor
EINECS	Contact for details

Quality Control

Our Tariquidar is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets high-grade standards suitable for research and development. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes. Our commitment to cGMP principles ensures consistency and reliability for your critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and should be stored in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider desiccated conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.