Description

Compstatin CAS NO 206645-99-0 is a potent and selective cyclic peptide inhibitor of the complement component C3, a central protein in the complement system cascade. This compound is a critical research tool and therapeutic candidate for modulating the complement pathway, which is implicated in a wide range of inflammatory and autoimmune disorders. It is primarily utilized by pharmaceutical researchers, biotechnology companies, and academic institutions focused on immunology, drug discovery, and the development of treatments for complement-mediated diseases.

Application

• Biomedical Research: Fundamental tool for studying the classical, lectin, and alternative pathways of the complement system in vitro and in vivo.
• Drug Discovery & Development: Serves as a lead compound and reference standard for developing novel therapeutics targeting C3 for conditions like age-related macular degeneration (AMD), paroxysmal nocturnal hemoglobinuria (PNH), and atypical hemolytic uremic syndrome (aHUS).
• Inflammatory Disease Models: Used to validate the role of complement C3 in animal models of ischemia-reperfusion injury, sepsis, and autoimmune diseases.
• Diagnostic Assay Development: Employed as a specific inhibitor in assay kits and protocols to measure complement activity and screen for complement inhibitors.

Basic Information

Product Name	Compstatin
CAS No.	206645-99-0
Molecular Formula	C₇₀H₁₀₂N₂₀O₂₂S₂
Molecular Weight	1635.8 g/mol
Synonyms	Compstatin; Complement C3 Inhibitor, Compstatin; Cyclo(1,6)-[Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys]-Thr-NH2; Acetyl-Thr-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-NH2 (cyclic 1-13 disulfide); Complement Inhibitor Compstatin; C3 Inhibitor Peptide
EINECS	Contact for details

Quality Control

Our Compstatin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided to ensure the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.