Description

Gw9662 is a potent and selective peroxisome proliferator-activated receptor gamma (PPARγ) antagonist. This compound is a critical research tool for studying adipogenesis, insulin sensitivity, and inflammatory pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in metabolic disease and cancer research. The product, also known by its CAS number 205827-96-9, is supplied as a high-purity biochemical for laboratory use.

Application

• Pharmacological Research: Used as a standard PPARγ antagonist to investigate receptor function and signaling pathways.
• Metabolic Disease Studies: Essential for in vitro and in vivo research on diabetes, obesity, and insulin resistance mechanisms.
• Cell Biology: Employed to inhibit adipocyte differentiation and study lipid metabolism in cell culture models.
• Inflammation and Immunology: Applied in research exploring the role of PPARγ in macrophage polarization and inflammatory responses.
• Oncology Research: Investigated for its potential effects on cancer cell proliferation and tumor growth regulation.
• Drug Discovery: Serves as a reference compound and a starting point for the development of novel PPARγ-targeting therapeutics.

Basic Information

Product Name	Gw9662
CAS No.	205827-96-9
Molecular Formula	C17H14N2O3S
Molecular Weight	326.37 g/mol
Synonyms	GW-9662; GW 9662; 2-Chloro-5-nitro-N-phenylbenzamide; PPARγ Antagonist GW9662; 2-Chloro-5-nitrobenzanilide; BRN 8239238; UNII-66M6ZP8G8G; CHEMBL868
EINECS	Contact for details

Quality Control

Our Gw9662 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR/IR for structural confirmation, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.