Description

Fmoc-Tyr-Ala-Diazomethylketone is a specialized, high-purity protected tripeptide building block designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise, site-specific incorporation of a reactive diazomethyl ketone warhead into peptide sequences. It is primarily utilized in the development of protease inhibitors, activity-based probes, and other bioactive peptides within the pharmaceutical and life sciences research sectors.

Application

• Protease Inhibitor Development: Serves as a key intermediate for synthesizing irreversible, mechanism-based inhibitors targeting specific proteases.
• Activity-Based Protein Profiling (ABPP): Used to create chemical probes that covalently label active sites of enzymes for functional proteomics studies.
• Peptide-Based Drug Discovery: Enables the construction of peptide libraries and lead compounds with enhanced binding affinity and specificity.
• Biochemical Research: Acts as a crucial reagent for studying enzyme mechanisms, substrate specificity, and protein-protein interactions.
• Solid-Phase Peptide Synthesis (SPPS): Employed as an Fmoc-protected amino acid derivative for automated and manual peptide assembly.

Basic Information

Product Name	Fmoc-Tyr-Ala-Diazomethylketone
CAS No.	205763-22-0
Molecular Formula	C29H26N4O6
Molecular Weight	526.54 g/mol
Synonyms	Fmoc-Tyr-Ala-CHN2; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tyrosyl-L-alanine diazomethyl ketone; Fmoc-L-Tyrosyl-L-alanine diazomethyl ketone; (2S)-2-[[(2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoic acid 2-diazo-1-oxoethyl ester; Fmoc-Y-A-CHN2; Fmoc-Tyr(tBu)-Ala-CHN2 (related protected form); Peptide building block 205763-22-0
EINECS	Contact for details

Quality Control

Our Fmoc-Tyr-Ala-Diazomethylketone is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.